Remark 11.9.4.4. Let $F: \operatorname{\mathcal{C}}\rightarrow \operatorname{\mathcal{D}}$ and $G: \operatorname{\mathcal{D}}\rightarrow \operatorname{\mathcal{C}}$ be locally small $\infty $-categories, with $\operatorname{Hom}$-functors
Combining Corollary 11.9.4.3 and Proposition 8.3.4.1, we obtain homotopy equivalences
In particular, every natural transformation of functors $\eta : \operatorname{id}_{ \operatorname{\mathcal{C}}} \rightarrow G \circ F$ determines a natural transformation of profunctors $\eta ': \mathscr {H}_{\operatorname{\mathcal{D}}}( F(-), -) \rightarrow \mathscr {H}_{\operatorname{\mathcal{C}}}( -, G(-) )$, which is characterized up to homotopy by the requirement that the diagram
commutes in the homotopy category $\mathrm{h} \mathit{ \operatorname{Fun}( \operatorname{\mathcal{C}}^{\operatorname{op}} \times \operatorname{\mathcal{C}}, \operatorname{\mathcal{S}}) }$.